منابع مشابه
Rat basophilic leukemia cells stiffen when they secrete
RBL cells provide a useful model of the IgE and antigen-dependent stimulus-secretion coupling of mast cells and basophils. We have measured cellular deformability to investigate the participation of cytoskeletal mechanical changes. Cross-linking cell-surface IgE-receptor complexes with multivalent ligands not only triggered secretion but also caused the cells to stiffen, i.e., to become more re...
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VEINS, like the large arteries (8, 16, 21), stiffen with increasing age (6, 11–12, 14, 18, 20). From a cardiovascular control perspective, venous capacitance, which relates the magnitude of the total contained volume of the vasculature to the pressure (i.e., the volume at a given internal pressure), is vitally important to long-term blood pressure regulation. In animal models, this is measured ...
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Reconstituted filamentous actin networks with myosin motor proteins form active gels, in which motor proteins generate forces that drive the network far from equilibrium. This motor activity can also strongly affect the network elasticity; experiments have shown a dramatic stiffening in in vitro networks with molecular motors. Here we study the effects of motor generated forces on the mechanics...
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Curved thin sheets are ubiquitously found in nature and manmade structures from macro- to nanoscale. Within the framework of classical thin plate theory, the stiffness of thin sheets is independent of its bending state for small deflections. This assumption, however, goes against intuition. Simple experiments with a cantilever sheet made of paper show that the cantilever stiffness largely incre...
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The cellular and cytokine network that regulates the human IgE synthesis has recently been clarified. In contrast to intracellular bacteria, that induce the activation of helper T cells producing IFN-,, but not IL-4 (WH cells), allergens and helminths preferentially activate helper T cells that produce IL-4, but not IFN-, (TH cells). TH cells provide the B cells with both signals (T/B cell cont...
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ژورنال
عنوان ژورنال: Cell Chemical Biology
سال: 2018
ISSN: 2451-9456
DOI: 10.1016/j.chembiol.2018.05.006